How lifestyle and environment reshape the sperm epigenome and why it matters for fertility, embryos and child health

How lifestyle and environment reshape the sperm epigenome and why it matters for fertility, embryos and child health

Epigenetic signatures in sperm. Sperm chromatin is tightly packaged by binding to protamines and histones (< 15% of the genome). DNA methylation occurs at CG-rich, histone-bound DNA regions and repetitive sequences. Environmental factors may influence DNA methylation, histone modification, as well as the expression of small non-coding RNA, such as tsRNA, microRNA, and PIWI-interacting RNA. The…

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Review reveals how paternal lifestyle shapes sperm epigenetics and offspring health

Review reveals how paternal lifestyle shapes sperm epigenetics and offspring health

A new review in Clinical Epigenetics synthesises growing evidence that paternal lifestyle and environmental exposures such as diet, obesity, smoking, endocrine-disrupting chemicals, and stress alter sperm epigenetic marks (DNA methylation, histone retention, and small non-coding RNAs). These changes can influence sperm quality and fertilising ability, early embryo development, assisted reproduction outcomes, and long-term health risks…

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20 of the best places to visit in February

20 of the best places to visit in February

By February, those new year parties (and resolutions) are a distant memory — and it seems a very long way to go before summer. Booking a holiday is the perfect way to get through the short, dark days and there are plenty of enticing options, however far you fancy travelling. If you’re craving sunshine, look…

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General health and lifestyle

General health and lifestyle

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World Menopause Day: Lifestyle Medicine

World Menopause Day: Lifestyle Medicine

WASHINGTON — World Menopause Day is Oct. 18, and this year the International Menopause Society is spotlighting lifestyle medicine — the everyday habits that can reduce symptoms and support long-term health. With more than a billion women moving through this transition worldwide, the goal is simple: better information, better care and practical advice. Here, we’ll…

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清零

戀棧

立法會選舉在即,發現主席宣布不再參選後,亦有好幾位議員發出不再參選信息,朝代更換年輕政客取替舊人是慣常現象,但元老級政客繼續爭取長期留守也非罕見。 三國時,曹魏名臣蔣濟譏曹爽的話:「駑馬戀棧豆,必不能用也。」意思是馬匹若留戀在馬棚吃棧豆(高級的馬飼料),就算多好的馬也無用武之地。 曹爽本是魏國忠良之徒,甚受器用,明帝駕崩後,八歲太子曹芳登基,任命司馬懿和曹爽為輔政大臣,惟曹爽千方百計架空司馬懿獨攬大權,掌握權力後,便過着皇帝般的奢華生活,「戀棧」這句話是司馬懿對曹爽的譏諷,最終引發高平陵之變,曹爽投降後被誅滅三族。 小小歷史故事把「戀棧」這詞流傳二千多年至今,適用於留戀功名利祿不斷嘗試保存自我地位攬勢的人,任何機構都可能遇上戀棧之人,醫生在大學服務近三十年,不禁要自我檢討一下是否有點「戀棧」。 回看過去工作或所謂成就,換來的絕非權力,也並非金錢(大學薪金不錯但絕非致富之途)。最大得着是一份尊重,研究有成果將得到同行尊重,醫病有成果得到病人尊重,若「尊重」算是棧豆,那麼醫生也可算是戀棧。 其實說到底,理他戀棧不戀棧,最緊要就是活得夠「㜺鬼」。 撰文 : 莫樹錦 欄名 : 醫筆稱心 Source link

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Hong Kong lifestyle medicine summit to champion holistic vision for health

Hong Kong lifestyle medicine summit to champion holistic vision for health

As Hong Kong grapples with a rise in chronic diseases like cardiovascular issues, cancer and diabetes, a growing frustration is emerging: the conventional medical model, focused on quick diagnosis and prescriptive medication, often falls short of addressing the causes of these long-term illnesses. Determined to bridge this gap, local health professionals Tricia Yap and Denise…

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