Milan will look to Rafael Leao and Christian Pulisic in the Derby della Madonnina against Inter, while Cristian Chivu will look to Francesco Pio Esposito and Ange-Yoan Bonny.
It kicks off at 20:45 CET (19:45 GMT) at the Stadio Maradona in San Siro, Milan.
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Inter are the table leaders with a 10-point advantage over their city rivals.
The Nerazzurri, however, are without their captain and best scorer, Lautaro Martinez, while Marcus Thuram has had fever and is unlikely to start.
Milan must cope without Santiago Gimenez, Matteo Gabbia and Ruben Loftus-Cheek. Davide Bartesaghi is available after suffering a minor injury against Cremonese last weekend, so Pervis Estupinan is the favourite to start as a left midfielder.
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MILAN, ITALY – NOVEMBER 23: Christian Pulisic of AC Milan competes for the ball with Manuel Akanji of FC Internazionale during the Serie A match between FC Internazionale and AC Milan at Giuseppe Meazza Stadium on November 23, 2025 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
According to several sources, including Gazzetta and Sky Sport Italia, Hakan Calhanoglu will start on the bench for Inter, with Nicolò Barella, Piotr Zielinski and Henrikh Mkhitaryan getting the nod in central midfield.
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Milan will look to Pulisic and Leao in attack, with Niclas Fullkrug and Christopher Nkunku available on the bench.
Milan vs. Inter – where to watch on TV
The match will be broadcast live on TNT Sports 1 and DAZN in the UK and Ireland and on Paramount+ in the USA. Football Italia will provide live updates via a live blog.
MILAN, ITALY – NOVEMBER 23: A general view of the stadium during the Serie A match between FC Internazionale and AC Milan at Giuseppe Meazza Stadium on November 23, 2025 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
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Milan vs. Inter – probable line-ups
Milan (3-5-2): Maignan; Tomori, De Winter, Pavlovic; Saelemaekers, Fofana, Modric, Rabiot, Estupiñán; Leão, Pulisic.
Inter (3-5-2): Sommer; Bisseck, Akanji, Bastoni; Luis Henrique, Barella, Zielinski, Mkhitaryan, Dimarco; Esposito, Bonny.
