A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors
IC declines with age Using clinical assessment tools, we developed an IC score that represents combined age-related decline in five domains: cognition; locomotion; sensory (vision and hearing); psychological; and vitality (Methods) (Fig. 1a). IC scores ranged from 0 to 1, with 1 indicating the best possible health outcome and 0 representing the worst. We examined…