Robert de Pauw has left Aston Villa after just a six-month spell in charge.
Villa are ninth in the Women’s Super League after Sunday’s 4-0 defeat by Arsenal, and sit just one point above the relegation zone.
The Dutchman, 43, was appointed in June after Carla Ward stepped down from her role at the end of last season.
“We would like to thank Robert for his commitment during his time in charge and wish him well for the future,” said a Villa statement on Wednesday.
The club confirmed assistant head coach Shaun Goater will take interim charge until a new manager is appointed.
Villa have won just one game under De Pauw in the WSL this season – a late 3-2 victory last month over bottom-of-the-table Crystal Palace.
They finished seventh in the WSL last season after finishing in a club-record high of fifth place under Ward in 2022-23.
However, they have claimed just six points from their opening nine games this season.
Villa face Charlton Athletic in the Women’s League Cup later on Wednesday, with only a win able to give them a chance of claiming a place in the knockout stage.