Chelsea are hopeful that Cole Palmer will recover in time from the knock he sustained against Manchester United last weekend.
Jaden Sancho, who has not played since mid-October because of illness, could be available.
Arsenal will assess midfielder Declan Rice, who missed the midweek European defeat by Inter Milan with a minor foot injury.
Martin Odegaard, who played for the first time since the end of August in a cameo substitute appearance against Inter, could feature again.
Kai Havertz suffered a nasty cut to the head in midweek and is being monitored, as is Mikel Merino, who was taken off at half-time with illness.
On-loan Raheem Sterling is ineligible to face his parent club.
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