Until recently, doctors prescribed an antidepressant medication from only a single class of drugs, one medication at a time, called monotherapy.
Doctors generally start at a lower dosage and increase it before ruling it out as ineffective. If that happens, they might try another medication within that class or switch to another class of antidepressants entirely.
Bupropion
On its own, bupropion effectively treats MDD. But a doctor may also prescribe it with other medications for depression that is difficult to treat.
However, in-depth studies on its use as a combination medication aren’t available.
Antipsychotics
Current research also suggests a benefit of taking SSRIs and an antipsychotic for those with MDD with psychosis.
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Carefully consider the pros and cons of antipsychotics with your doctor. Their side effects may prolong or worsen some depression symptoms.
L-triiodothyronine
Some doctors use L-triiodothyronine (T3) in combination with SSRIs.
Research from 2021 suggests that T3 with an SSRI may lead to a faster response to treatment compared with taking an SSRI alone for older men. But more research is necessary.
The typical starting dose of T3 is 25 micrograms (mcg) daily. If that dosage doesn’t provide the desired results after 1 to 2 weeks, they may increase it to 50 mcg daily.
Stimulants
Dextroamphetamine (Dexedrine) and methylphenidate (Ritalin) are stimulants that medical professionals may use to treat depression. Doctors may prescribe them alone or in combination with antidepressant medications.
However, not all clinical trials have shown benefits from this strategy.
Stimulants are most helpful when the desired effect is a quick response. People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination.
