The familiar duo of Russell and Ben White and Finn Russell start as half-backs.
The players selected in the back three have amassed nearly 150 caps combined, with Darcy Graham starting alongside Duhan van der Merwe on the wings and Toulouse’s Blair Kinghorn at full-back.
Matt Fagerson, who won a 50th cap for Scotland against Australia in November, is named at the back of the scrum, with flankers Darge and Jamie Ritchie completing the back row.
At the front of the scrum, loosehead prop Pierre Schoeman lines up alongside Cherry, who is a surprise starter ahead of the benched Ewan Ashman, with Zander Fagerson at tighthead.
Gray joins Grant Gilchrist in the second row to complete the pack.
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